The ovarian tumor (otu) gene behaves as if it encodes a product (OGP) which is required during several early steps in the transformation of oogonia into functional oocytes. The ovarian phenotypes produced by various EMS‐induced mutations can be explained as graded responses by individual mutant germ cells to the different levels of functionally active OGP they themselves synthesize. In addition, genetic evidence suggests that otu also encodes a second product that is utilized late in oogenesis. Molecular studies of the otugene (...) demonstrate that it does transcribe at least two ovaryspecific RNAs. The possible function of the otu product in the cellular divisions that give rise to the oocyte and its sister nurse cells is discussed. (shrink)

I wrote the following essay in early 2006 while still a member of the Lutheran Church -- Missouri Synod. On the Vigil of Pentecost in A.D. 2007 (May 25th) I was formally received into the fellowship of the Roman Catholic Church at the parish of St. Louis the King of France in Austin, Texas.

In medieval England, as in the rest of Christian Europe, marriages contracted privately and solely by the exchange of words of present consent — something like “I here take you as my legitimate wife [husband]” — were considered binding even without consummation from the late twelfth century. Such marriages would be enforced by the ecclesiastical courts, even if the enforcement required a divorce between a man and woman solemnly married in church. Such a divorce, of course, was never a divorce (...) in the modern sense, but rather an annulment, a judicial declaration that since one of the parties to that church ceremony had already been married, the ecclesiastical ceremony had not produced a marriage at all. The original, privately contracted marriage stood in full force. The moral problems faced by the ecclesiastical courts in such matters were substantial; the problems presented for the king's court, particularly in matters relating to property rights, were no less so. (shrink)

Robert Stalnaker is an actualist who holds that merely possible worlds are uninstantiated properties that might have been instantiated. Stalnaker also holds that there are no metaphysically impossible worlds: uninstantiated properties that couldn't have been instantiated. These views motivate Stalnaker's "two dimensional" account of the necessary a posteriori on which there is no single proposition that is both necessary and a posteriori. For a (metaphysically) necessary proposition is true in all (metaphysically) possible worlds. If there were necessary a posteriori (...) propositions, that would mean that there were propositions true in all possible worlds but which could only be known to be true by acquiring empirical evidence. Consider such a purported proposition P. The role of empirical evidence for establishing P's truth would have to be to rule out worlds in which P is false. If there were no such worlds to be ruled out, we would not require evidence for P. But by hypothesis, P is necessary and so true in all metaphysically possible worlds. And on Stalnaker's view, the metaphysically possible worlds are all the worlds there are. So there can be no proposition that is true in all possible worlds, but that we require evidence to know. In this way, the motivation for Stalnaker's two dimensional account of the necessary a posteriori rests on his denying that there are metaphysically impossible Worlds. I argue that given his view of what possible worlds are, Stalnaker has no principled reason for denying that there are metaphysically impossible worlds. If I am right, this undercuts Stalnaker's motivation for his two dimensional account of the necessary a posteriori. (shrink)

The Greek philosopher Aristotle, writing over two thousand years before Wall Street, called people who engaged in activities which did not contribute to society "parasites." In his latest work, renowned scholar Robert C. Solomon asserts that though capitalism may require capital, but it does not require, much less should it be defined by the parasites it inevitably attracts. Capitalism has succeeded not with brute strength or because it has made people rich, but because it has produced responsible citizens and--however (...) unevenly--prosperous communities. It cannot tolerate a conception of business that focuses solely on income and vulgarity while ignoring traditional virtues of responsibility, community, and integrity. Many feel that there is too much lip-service and not enough understanding of the importance of cooperation and integrity in corporate life. This book rejects the myths and metaphors of war-like competition that cloud business thinking and develops an "Aristotelean" theory of business. The author's approach emphasizes several core concepts: the corporation as community, the search for excellence, the importance of integrity and sound judgment, as well as a more cooperative and humane vision of business. Solomon stresses the virtues of honesty, trust, fairness, and compassion in the competitive business world, and confronts the problem of "moral mazes" and what he posits as its solution--moral courage. (shrink)

Defenders of physicalism often point to the reduction of chemistry to quantum physics as a paradigm for the reduction of the rest of reality to a microphysical foundation. This argument is based, however, on a misreading of the philosophical significance of the quantum revolution. A hylomorphic interpretation of quantum thermodynamics and chemistry, in which parts and wholes stand in a mutually determining relationship, better fits both the empirical facts and the actual practice of scientists. I argue that only a hylomorphic (...) interpretation of quantum mechanics is able to treat thermodynamic quantities, such as temperature and entropy, as genuinely real, which in turn provides grounds for the reality of the direction of time and of molecular structure. (shrink)

Government’s use of imprisonment raises distinctive moral issues. Even if government has broad authority to make and to enforce law, government may not be entitled to use imprisonment as a punishment for all the criminal laws it is entitled to make. Indeed, there may be some serious crimes that it is wrong to punish with imprisonment, even if the conditions of imprisonment are humane and even if no adequate alternative punishments are available.

In response to Frederick Schauer's book The Force of Law, I argue that the available evidence indicates that non-coercive law could influence many people's behavior. It may sometimes be best to forgo coercive enforcement of an important law.

Extensive case studies, questionnaires, and problem-solving exercises make this an essential guide for business people.

Reviews the book, Upheavals of thought: The intelligence of emotions by Martha C. Nussbaum . Drawing from an astounding array of sources, Nussbaum argues against the common understanding of emotions as irrational and animalistic impulses disconnected from our thoughts and reason. Rather, she argues that emotions are highly discriminating responses to what is of value and importance that are, therefore, suffused with intelligence and discernment. Nussbaum explores the structure of a wide range of emotions, in particular, compassion and love, in (...) order to show that there can be no adequate ethical theory without an adequate theory of emotional experience and meaning. 2012 APA, all rights reserved). (shrink)

Give style to your character, a great and rare art.Nietzsche Gay Science What are we to make of Nietzsche? There has been an explosion of scholarship over the past twenty years, much of it revealing and insightful, a good deal of it controversial if not polemical. The controversy and polemics are for the most part straight from Nietzsche, of course, and the scholarly disputes over what he ‘really’ meant are rather innocuous and often academic compared with what Nietzsche meant with (...) his conscientiously inflammatory rhetoric and hyperbole. We have been treated to extended debates about Nietzsche's politics, his attacks on Christianity and morality, his famed notion of the übermensch and his less lampooned doctrine of the ‘eternal recurrence’. We have recently heard Nietzsche reinterpreted as an analytic philosopher, as a deconstructionist, as a feminist, even as a closet Christian and a liberal. Stephen Aschheim suggests in his recent book that Nietzsche provides us with something like a Rorschach test, inviting readers with amazingly different commitments and ideologies to ‘make their own Nietzsche’. But there is another approach to Nietzsche, something quite different from interpreting him in terms of his various ‘theses’ and positions, unpacking his ‘system’ or repeating unhelpfully that he displayed no such coherence and consistency, something more than finding out ‘who’ Nietzsche is as opposed to what we have made out of him. The simplest way of getting at this alternative approach might be to ask, what Nietzsche would make of us? I grant that this is a bit cryptic, and it invites a variety of unflattering answers. But I think it is very much in the spirit of what he are all about. It is an intimately personal approach to Nietzsche, an approach that will, no doubt, be somewhat different for each and every one of us. But that, too, of course, is just what Nietzsche would have demanded. (shrink)

The Atlas of Reality: A Comprehensive Guide to Metaphysics presents an extensive examination of the key topics, concepts, and guiding principles of metaphysics. Represents the most comprehensive guide to metaphysics available today Offers authoritative coverage of the full range of topics that comprise the field of metaphysics in an accessible manner while considering competing views Explores key concepts such as space, time, powers, universals, and composition with clarity and depth Articulates coherent packages of metaphysical theses that include neo-Aristotelian, Quinean, Armstrongian, (...) and neo-Humean Carefully tracks the use of common assumptions and methodological principles in metaphysics. (shrink)

Some of the most interesting works in virtue ethics are the detailed, perceptive treatments of specific virtues and vices. This chapter aims to develop such work as it relates to intellectual virtues and vices. It begins by examining the virtue of intellectual humility. Its strategy is to situate humility in relation to its various opposing vices, which include vices like arrogance, vanity, conceit, egotism, grandiosity, pretentiousness, snobbishness, haughtiness, and self-complacency. From this list vanity and arrogance are focused on in particular. (...) Humble persons are not distinguished from arrogant persons by being unaware of or unconcerned with entitlements; rather, they lack the arrogance that entails a specific kind of motivation called ‘ego-exalting potency’. Humble people are motivated by pure interests regarding entitlements given their ability to serve as means to some valuable purpose or project. The chapter ends by considering a wide variety of ways intellectual humility can promote the acquisition of epistemic goods. (shrink)

For many philosophy teachers, the joy of philosophy is the joy of putting forward and defending arguments. However, this paper argues that the core of philosophy consists in a set of problems that are distinctive not because of their logic but because they deal with profound emotions that define the human condition and, as such, manifest an apparent immunity to logical analysis. In putting forward this position, the paper describes the current “thinness” of philosophy, argues that the familiar characterization of (...) philosophy as a subject matter concerned with rigorous argumentation is mistaken, and offers a list of resolutions that aim at teaching the joy of philosophy. (shrink)

Proponents of the dominant paradigm in evolutionary psychology argue that a viable evolutionary cognitive psychology requires that specific cognitive capacities be heritable and “quasi-independent” from other heritable traits, and that these requirements are best satisfied by innate cognitive modules. We argue here that neither of these are required in order to describe and explain how evolution shaped the mind.

Current scholarship has focused on analyzing how Arendt's storytelling corresponds to her political arguments. In following up this discussion, I offer a closer examination of the unusual myth Arendt uses to explain the condition of the modern age, a myth she refers to as the ?political nature of history.? I employ literary terms along with the standard vocabulary of political theory in shaping this reading of Arendt. Following Robert C. Pirro, I also consider Arendt's story as a tragedy, but (...) in the broadest sense, that of a collision of two goods, freedom and security. By describing Arendt's thought in this manner, I hope to reveal another way in which Arendt represents the call to action that she believes so crucial to humanity, as a summons to we flawed antiheroes through the device of a heroic myth. (shrink)

The most important intellectual in the Federal Republic of Germany for the past three decades, Habermas has been a seminal contributor to fields ranging from sociology and political science to philosophy and cultural studies. Although he has stood at the centre of concern in his native land, he has been less readily accepted outside Germany, particularly in the humanities. His theoretical work postulates the centrality of communication and understanding, and as such his strategy of debate is marked by a politically (...) informed unity of theory and practice. Holub's book is the first detailed account of the major debates in which Habermas has engaged since the early sixties. It stems from the conviction that his critics have not understood the political strategy behind his various interventions, or the consistency that informs his intellectual activities. Habermas is viewed in dialogue with important philosophical, sociological and political currents in West Germany. Holub demonstrates how Habermas pursues a course that incorporates various aspects of his opponents' positions, while simultaneously defending perceived threats to democracy and open discussion. (shrink)

In this work, Robert Solomon tries to put the fun back in philosophy, recapturing the heart-felt confusion and excitement that originally brings us all into philosophy. It is not a critique of comtemporary philosophy so much as it is an attempt to engage in philosophy in a different kind of way, beginning with a re-evaluation of Socrates and the nature of philosophy and defending the passionate life in contrast to the calm life of thoughtful contemplation so often held up (...) as an ideal by traditional philosophers. In short, it is an attempt to recapture the kind of philosophy that Nietzsche celebrated as a "joyful wisdom". The author tries to break down the walls between academic philosophy and its lost audience, between thin logic and thick rhetoric, between philosophical reason and philosophical passion, between 'analytic' and 'continental' philosophy, between philosophy and life. (shrink)

Multiple realization was once taken to be a challenge to reductionist visions, especially within cognitive science, and a foundation of the “antireductionist consensus.” More recently, multiple realization has come to be challenged on naturalistic grounds, as well as on more “metaphysical” grounds. Within cognitive science, one focal issue concerns the role of neural plasticity for addressing these issues. If reorganization maintains the same cognitive functions, that supports claims for multiple realization. I take up the reorganization involved in language dysfunctions to (...) deal with questions concerned with multiple realization and neural plasticity. Beginning with Broca’s case for localization and the nineteenth century discussion of “reorganization,” and returning to more recent evidence for neural plasticity, I argue that, in the end, there is substantial support for multiple realization in cognitive systems; I further argue that this is wholly consistent with a recognition of methodological pluralism in cognitive science. (shrink)

Recent empirical work on the virtue of gratitude raises questions about the limits of that research and its methods to address normative questions about gratitude. I distinguish two kinds of norms for the emotion of gratitude—norms of genuineness and norms of excellence. I examine two kinds of empirical studies that aim to establish or contribute to the norms for gratitude: a so-called “prototype” approach, and a narrative vignettes approach, finding the latter far superior, and suggest various refinements that might improve (...) accuracy. The main emotion types, of which gratitude is an example, have a conceptual structure that must be reflected in any normative analysis, and is far better reflected in the vignettes approach. Ultimately, however, formulation of norms of genuineness and of virtue must come from one or another tradition of careful reflection and debate about such concepts as gratitude; and the representatives of such traditions are philosophers and theologians. (shrink)

In recent decades, widespread rejection of positivism’s notorious hostility toward the philosophical tradition has led to renewed debate about the real relationship of philosophy to its history. How History Matters to Philosophy takes a fresh look at this debate. Current discussion usually starts with the question of whether philosophy’s past should matter, but Scharff argues that the very existence of the debate itself demonstrates that it already does matter. After an introductory review of the recent literature, he develops his case (...) in two parts. In Part One, he shows how history actually matters for even Plato’s Socrates, Descartes, and Comte, in spite of their apparent promotion of conspicuously ahistorical Platonic, Cartesian, and Positivistic ideals. In Part Two, Scharff argues that the real issue is not whether history matters; rather it is that we already have a history, a very distinctive and unavoidable inheritance, which paradoxically teaches us that history’s mattering is merely optional. Through interpretations of Dilthey, Nietzsche, and Heidegger, he describes what thinking in a historically determinate way actually involves, and he considers how to avoid the denial of this condition that our own philosophical inheritance still seems to expect of us. In a brief conclusion, Scharff explains how this book should be read as part of his own effort to acknowledge this condition rather than deny it. (shrink)

In our society, some aspects of life are off-limits to commerce. We prohibit the selling of children and the buying of wives, juries, and kidneys. Tainted blood is an inevitable consequence of paying blood donors; even sophisticated laboratory tests cannot supplant the gift-giving relationship as a safeguard of the purity of blood. Like blood, health care is too precious, intimate, and corruptible to entrust to the market.The hospice movement in the United States is approximately 40 years old. During these past (...) four decades, the concept of holistic, multidisciplinary care for patients who are suffering from a terminal illness has evolved from a modest, grassroots constellation of primarily volunteer-run and community-governed endeavors to a multimillion dollar industry where the surviving nonprofits compete with for-profit providers, often publicly traded, managed by M.B.A.-trained executives, and governed by corporate boards. The relatively recent emergence of for-profit hospice reflects an increasing commercialization of health care in the United States, the potentially adverse impact of which has been well documented. (shrink)

Linguists intuitions about language change can be captured by adynamical systems model derived from the dynamics of language acquisition.Rather than having to posit a separate model for diachronic change, as hassometimes been done by drawing on assumptions from population biology (cf.Cavalli-Sforza and Feldman, 1973; 1981; Kroch, 1990), this new modeldispenses with these independent assumptions by showing how the behavior ofindividual language learners leads to emergent, global populationcharacteristics of linguistic communities over several generations. As thesimplest case, we formalize the example of (...) two grammars and show that eventhis situation leads directly to a nonlinear (quadratic) dynamical system.We study this one parameter model in a variety of situations for differentkinds of acquisition algorithms and maturational times, showing howdifferent learning theories can have very different evolutionaryconsequences. This allows us to formulate an evolutionary criterion for theadequacy of grammatical and learning theories. An application of thecomputational model to the historical loss of Verb Second from Old French toModern French is described showing how otherwise adequate grammaticaltheories might fail the evolutionary criterion. (shrink)

The turn of the nineteenth century marked a rich and exciting explosion of philosophical energy and talent. The enormity of the revolution set off in philosophy by Immanuel Kant was comparable, by Kant's own estimation, with the Copernican Revolution that ended the Middle Ages. The movement he set in motion, the fast-moving and often cantankerous dialectic of `German Idealism', inspired some of the most creative philosophers in modern times: including G.W.F. Hegel and Arthur Schopenhauer as well as those who reacted (...) against Kant - Marx and Kierkegaard, for example. This volume traces the emergence of German Idealism from Kant and his predecessors through the first half of the nineteenth century, ending with the irrationalism of Kierkegaard. It provides a broad, scholarly introduction to this period for students of philosophy and related disciplines, as well as some original interpretations of these authors. Each chapter is written by a distinguished scholar in the field. A glossary of technical terms together with a chronological table of philosophical, scientific and other important cultural events are provided. (shrink)

Fifty years ago, two Princeton professors established game theory as an important new branch of applied mathematics. Game theory has become a celebrated discipline in its own right, and it npw plays a prestigues role in many disciplines, including ethics, due in particular to the neo-Hobbesian thinking of David Gauthier and others. Now it is perched at the edge of business ethics. I believe that it is dangerous and demeaning. It makes us look the wrong way at business, reinforcing a (...) destructive obsession with measurable outcomes and a false sense of competition. It falsely characterizes or insidiously advocates a style of human behavior that is utterly unacceptable. To put the matter quite crudely, a person who actually practiced the form of "rationality" advocated by game theory would be something of a monster. (shrink)

European and North American scholars explore the political philosophy of Aristotle, with particular attention to questions arising from the Politics and the Nicomachean Ethics.